AbaA and WetA govern distinct stages of Aspergillus fumigatus development
نویسندگان
چکیده
منابع مشابه
WetA bridges cellular and chemical development in Aspergillus flavus
Bridging cellular reproduction and survival is essential for all life forms. Aspergillus fungi primarily reproduce by forming asexual spores called conidia, whose formation and maturation is governed by the central genetic regulatory circuit BrlA→AbaA→WetA. Here, we report that WetA is a multi-functional regulator that couples spore differentiation and survival, and governs proper chemical deve...
متن کاملRegulation of Development in Aspergillus nidulans and Aspergillus fumigatus
Members of the genus Aspergillus are the most common fungi and all reproduce asexually by forming long chains of conidiospores (or conidia). The impact of various Aspergillus species on humans ranges from beneficial to harmful. For example, several species including Aspergillus oryzae and Aspergillus niger are used in industry for enzyme production and food processing. In contrast, Aspergillus ...
متن کاملabaA controls phialide differentiation in Aspergillus nidulans.
Aspergillus nidulans is an ascomycetous fungus that reproduces asexually by forming multicellular conidiophores and uninucleate spores called conidia. Loss of function mutations in the abacus A (abaA) regulatory locus result in formation of aberrant conidiophores that fail to produce conidia. Wild-type conidiophores form two tiers of sterigmata. The first tier, metulae, divide to produce the se...
متن کاملDistinct responses of human monocyte subsets to Aspergillus fumigatus conidia.
Aspergillus fumigatus is an environmental fungus that causes life-threatening infections in neutropenic patients. In the absence of intact innate immunity, inhaled A. fumigatus spores (conidia) germinate in the lung, forming hyphae that invade blood vessels and disseminate to other tissues. Although macrophages and neutrophils are postulated to provide defense against invasive fungal infection,...
متن کاملInvestigation of the presence of brlA, abaA, and wetA conidiation genes in Dermatophytes
Background: Dermatophytes are common causes of cutaneous infections in humans and animals, which mostly reproduce by an asexual process. Such types of reproduction in many filamentous fungi are usually regulated by brlA, abaA, and wetA genes. The presence of these genes in dermatophytes was investigated. Materials & Methods: Conidiation genes represented by brlA, abaA, and wetA were dete...
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ژورنال
عنوان ژورنال: Microbiology
سال: 2011
ISSN: 1350-0872,1465-2080
DOI: 10.1099/mic.0.044271-0